Objective To compare the efficacy of laparoscopic iliopectineal ligament suspension with traditional vaginal hysterectomy plus anterior and posterior vaginal wall repair. Methods A total of 82 patients with POP who received treatment in the hospital from February 2020 to October 2021 were selected and divided into study group (n=41) and control group (n=41) by random number table method.The control group received traditional vaginal hysterectomy plus anterior and posterior vaginal wall repair, while the study group received laparoscopic iliopectineal ligament suspension plus anterior and posterior vaginal wall repair. Both groups were evaluated 6 months after operation. The surgical indicators, pelvic floor functional anatomic parameters, pelvic floor function, sexual life quality and complications of the two groups were compared. The objective cure rate and recurrence rate of the two groups were recorded 12 months after surgery. Results The amount of intraoperative blood loss in the study group was lower than control group (P<0.05), the postoperative vaginal length in the study group was longer than control group (P< 0.05), and the postoperative hospitalization and operation time in the study group were shorter than control group (P<0.05).In the study group, the difference between anterior vaginal wall protuberance and the farthest distance from hymen (Ba), posterior vaginal wall protuberance and the farthest distance from hymen (Bp), the median line of anterior vaginal wall and 3cm from hymen (Aa), the stump of vagina after hysterectomy or the farthest end of cervix resection (C), and the median line of posterior vaginal wall and 3cm from hymen (Ap) before and after surgery was lower than control group (all P<0.05). The difference of pelvic floor distress inventory-20(PFDI-20)scores and pelvic floor impact questionnaire-short form 7(PFIQ-7)scores before and after surgery in the study group was higher than that in the control group (all P<0.05). The difference of pelvic organ prolapse/urinary incontinence questionnaire (PISQ) score and female sexual function index(FSFI) score before and after operation in the study group was higher than that in the control group (all P<0.05). The total complication rate of study group was lower than control group (P<0.05).The objective cure rate of the study group was higher than control group (P<0.05), and the recurrence rate of the study group was lower than control group (P<0.05). Conclusion Compared with anterior and posterior vaginal wall repair plus traditional vaginal hysterectomy, anterior and posterior vaginal wall repair plus laparoscopic iliopectineal ligament suspension can shorten the hospital stay and operation time of POP patients, with accurate efficacy, reduce surgical trauma, increase vaginal length, improve sexual life quality, pelvic floor function and anatomical parameters, reduce the risk of recurrence, and have good safety.