1.Heilongjiang University of Traditional Chinese Medicine;2.The First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine
复发性流产（recurrent spontaneous abortion, RSA）的发生率逐年提高，严重威胁了女性生殖健康，随着国家三胎政策的开展，生育需求随之提高，但RSA病因学机制错综复杂，至今仍有50%病因不明。随着研究的深入，发现维生素D（vitamin D ,VD）在女性生殖疾病中起到重要作用，RSA患者普遍存在VD缺乏的状态，随着VD水平的下降，流产风险升高。VD与遗传、感染、血栓前状态、内分泌及免疫都具有相关性，直接或间接参与了RSA的发病。本文就VD与RSA的病因学机制研究作一综述。
The incidence of recurrent spontaneous abortion (RSA) is increasing year by year, which seriously threatens women's reproductive health. With the development of the national triplet policy, the reproductive demand is increasing, but the etiological mechanism of RSA is complicated, and 50% of the causes are still unknown. With the deepening of research, it is found that vitamin D (VD) plays an important role in female reproductive diseases, and RSA patients are generally in a state of VD deficiency. With the decline of VD level, the risk of abortion increases. VD is related to heredity, infection, prethrombotic state, endocrine and immunity, and directly or indirectly participates in the pathogenesis of RSA. In this paper, the etiological mechanism of VD and RSA is reviewed.