目的 探讨年龄相关性白内障（ARC）患者血清和房水白细胞介素-34（IL-34）水平及与炎症 因子的关系。方法 选取2018 年1 月—2018 年12 月在中国人民解放军新疆军区总医院全军眼科中心治疗的 ARC 患者150 例（150 眼）作为观察组，同期眼外伤患者150 例作为对照组。采用酶联免疫吸附试验测定血 清和房水IL-34、超敏C 反应蛋白（hs-PCR）、白细胞介素-1β（IL-1β）、白细胞介素-6（IL-6）、肿瘤 坏死因子-α（TNF-α）水平。结果 观察组血清IL-34、hs-PCR、IL-1β、IL-6、TNF-α 水平高于对 照组（P <0.05）。观察组房水IL-34、hs-PCR、IL-1β、IL-6、TNF-α 水平高于对照组（P <0.05）。观察 组血清IL-34 水平与hs-PCR、IL-1β、IL-6、TNF-α 水平呈正相关（r =0.512、0.564、0.531 和0.524，均 P =0.000）。观察组房水IL-34 水平与hs-PCR、IL-1β、IL-6、TNF-α 水平呈正相关（r =0.557、0.603、 0.581 和0.532，均P =0.000）。结论 ARC 患者血清和房水IL-34 水平升高，可能通过与其他促炎因子相互作 用参与疾病的发病过程。
Objective To investigate the levels of interleukin 34 (IL-34) in serum and aqueous humor of patients with age-related cataract and their relationship with inflammatory factors. Methods Totally 150 cases (150 eyes) of age-related cataract treated were selected as the observation group from January 2018 to December 2018 in the China People’s Liberation Army Xinjiang Military Region General Hospital All Army Eye Center, and 150 patients with ocular trauma were selected as the control group during the same period. Enzyme-linked immunosorbent assay was used to determine the levels of serum and aqueous humor IL-34, high-sensitivity C-reactive protein (hs- PCR), IL-1β, IL-6 and tumor necrosis factor-α (TNF-α). Results The serum levels of IL-34, hs-PCR, IL-1β, IL-6 and TNF-α in the observation group were higher than those in the control group (P < 0.05). The levels of IL-34, hs- PCR, IL-1β, IL-6 and TNF-α in the aqueous humor of the observation group were higher than those of the control group (P < 0.05). There was positive correlation between serum IL-34 level and the levels of hs-PCR, IL-1β, IL-6 and TNF-α in the observation group (r = 0.512, 0.564, 0.531 and 0.524, all P = 0.000). The level of IL-34 in the aqueous humor of the observation group were positively correlated with the levels of hs-PCR, IL-1β, IL-6 and TNF-α (r = 0.557, 0.603, 0.581 and 0.532, all P = 0.000). Conclusion The serum and aqueous humor IL-34 levels of patients with age-related cataract are elevated, which may be involved in the pathogenesis of the disease through interaction with other pro-inflammatory factors.